Artificial Intelligence for Healthcare

Expanding Horizons of Knowledge

What we do

AI for CardioMetabolic Domain

We simplify the complexity of biomedical analytics and build models that make data-driven decisions in minutes, not months. We provide specialized technical know-how and tools to model, integrate, cleanse, prepare, analyze and visualize big biomedical data. HORAIZON has developed a portfolio of state-of-the-art machine learning techniques that allow highly efficient, parallelized analysis of the data in cloud environment and visualisation of the results.

From developing personalised treatment strategies to solving complex business problems, we believe that the world’s most challenging issues can be solved with data. Get in touch with us to discover how our predictive models can add value to your business.

Our DeepBiomics platform allows reliable and fast analysis of complex biomedical datasets. It can combine multiple evidence from heterogeneous data sources.

Our predictive models

DeepBiomics platform

Our platform provides algorithms that are readily available to analyze heterogeneous data from multiple technologies such as metagenomics, proteomics, epigenetics, protein 3D structural data, gene ontology and pathway databases, cell images, and an enormous amount of textual data.

Our specialized graph and network based representations allow summarizing complex systems as components (nodes) and interactions (edges) between them. For instance, in cellular systems nodes are proteins or gene sequences, while the edges are functional interactions among them.

Microbiome analysis

Type 2 Diabetes and Deepbiomics

Type 2 Diabetes (T2D) is a metabolic disease, which is highly prevalent across the world. Novel insights are needed regarding the possible mechanisms and pathways that could play a role in the development ofT2D. Recent efforts have suggested that the gut microbiome might play arole in the progression of the disease. HORAIZON team is building advanced machine learning models to analyse the microbiome 16S/shotgun data from a multi-ethnic healthy vs T2D cohort to see if we can identify specific microbiome components that are important for prediction.

Our methods can link these components to the specific pathways and mechanisms, serving as guidance for new clinical research. Furthermore, we observe that prevalence of T2D differs across different ethnicities. Thus, we develop ethnicity specific models that allow optimal prediction based on ethnicity-tailored microbial biomarkers.

Proteome analysis

Cardiovascular risk prediction

In the era of personalized medicine, it is of utmost importance to beable to identify subjects at highest cardiovascular risk. To date, single biomarkers have failed to markedly improve estimation of cardiovascular risk. HORAIZON team has developed novel machine learning models to simultaneously identify most relevant biomarkers that may hold promise to improve prediction of cardiovascular event.

Our protein-based risk model is trained on large scale data and is also compared with traditional risk factors in predicting CV-events in the primary prevention setting followed by extensive validation on independent cohort. Proteome-based models developed by HORAIZON, notably outperform traditional clinical risk factors in predicting the risk of cardiovascular events.

Epigenetics analysis

Response to the treatment

The use of biologics, such as anti-TNF, has revolutionized the care of patients with Crohn’s disease. Nevertheless, up to 70% of patients do not respond to such biologic treatment or lose response over time. Current treatment algorithms are largely based on atrial-and-error approach because no biologic parameters have been identified that predict treatment success or failure. As such, many patients receive ineffective treatment for many months to years. This (lack of) strategy has been associated with severe complications such as obstructions and perforations (end organ damage) and need for repeated surgical resections, stomas and cancer.

Personalized medicine, including prediction of treatment response to individual agents could shorten the time period to ‘deep remission’ significantly and would bring along a major improvement in the prognosis of this dreadful condition. HORAIZON team has introduced novel machine learning models, discovering specific epigenetic patterns in the peripheral blood at baseline (before start of treatment) that were associated with treatment response (clinical remission and mucosal repair) to several biologic agents. As such, epigenetic marks hold great promise as predictors of therapy response.The differential patterns that were identified for the individual treatments, would allow personalized treatment in the near future.

With contribution by E. Levin, PhD

Multi-omics in medicine (in Dutch)

From developing personalised treatment strategies to solving complex business problems, we believe that the world's most challenging issues can be solved with data.

Analyse all you data. Smarter and Faster.

You have a lot of data, in many different formats, in lots of different locations. Some of it is in the cloud, some of it is in various legacy databases, some of it is in spreadsheets on your desktop. You’ve got big data. You would like to analyze and gain business insights from it. That’s where HORAIZON comes in. HORAIZON solutions help integrating, analyzing and getting insight from all your data. Smarter and faster.

Methodology

Deep Learning

We use state-of-the-art Deep Learning techniques to help to make sense of data such as images, sound, and text. These algorithms, inspired by biological neural networks, allow building highly predictive models for structured and heterogeneous data.

Multi-View Methods

Our custom made algorithms, based on kernel methods framework, allow modelling and analysis of non-linear interactions in the data. These methods are fully optimized for large scale computations on thousands of processors.

Intelligible Models

Our sparse models are a particularly useful in many applications where the main objective is to discover predictive patterns in data for enhancing our understanding of underlying biological processes, beyond just building accurate 'black-box' predictors.

Our algorithms are optimized to use various large scale, high-performance frameworks and conducting parallel computations on thousands of processors simultaneously.

Our services are provided with NLdigital terms and conditions.

About us

Founded in 2015 by Dr. Evgeni Levin, HORAIZON Technology BV is an innovative AI company with a team of brilliant, PhD level data scientists and engineers. We are a trusted partner in industrial and scientific collaborations involving leading multinational companies in healthcare and cardiometabolic domain.

 

KVK 62892789

Vestigingsnr. 000031860672

Marshalllaan 2 2625 GZ, Delft

The Netherlands

email: info@horaizon.nl